Shawn Bean | Mitolife Radio Ep #195

SUMMARY KEYWORDS
glutathione, pathway, shawn, high, lyme, potassium, acid, practitioners, milligrams, body, magnesium, people, started, b12, unintelligible, lactoferrin, day, sulfur, taurine, add
SPEAKERS
Matthew Blackburn, Shawn Bean

Matthew Blackburn  00:17
You're listening to Episode 195 of Mito Life Radio. I'm your host, Matt Blackburn and today, I'm interviewing Shawn Bean. Shawn Bean is a functional medicine specialist, a clinical nutritionist. He has a Bachelors of Science in Exercise Science and earned multiple certifications from the World Institute of Integrative Health Science. He is certified in Neuroendo-immunology, NLP and clinical hypnotherapy. He has studied the neurology of autism, depression, chronic fatigue, lyme, weight loss, GI imbalances, environmental toxicity, hormones, genetic mutations, nutrition, lifestyle modifications, and lot more. He is also a former competitive bodybuilder, and a lot of fun to talk to. I took so many notes in this interview. He's really an encyclopedia of knowledge and it's amazing that he can remember all the stuff that he does. He shares his journey of recovering from low testosterone, alkaline phosphatase imbalance. He explains what being floxed means. A lot of people have been dealing with that and so he shares his journey of how he recovered from using fluoroquinolones class of antibiotics. He talks about different genetic mutations, different pathways, the NRF2 pathway, he talks about mold toxicity, MTHFR sulphation, glucuronidation, Pyro glutamic acid, he covers a lot of ground, so definitely be ready to take notes with this episode, we dive pretty deeply into B12, on how to transport it, utilize it. He's a huge fan of glutathione not necessarily supplements, but just the glutathione system. So he talks quite a bit about glutathione and why it's so important. He talks about lactoferrin the arachidonic acid and EPA ratio, H. pylori, Saccharomyces boulardii therapy, and so much more. So enjoy the show. Here is Shawn Bean. Okay, we're here with Shawn Bean. Welcome to the show.

Shawn Bean  02:49
It's a pleasure to be here, Matt.

Matthew Blackburn  02:51
Yeah, this is a long time coming. We've been talking, I think off and on for a few years and I really appreciate how you really pick apart protocols and information and dive deep into the literature to find out what's going on. Before we started recording, we were talking about B12 and calcification, and glutathione. And these are all huge topics, where, you know, protocols have been built around them and sub routines or whatever. But what you realize is there's so much nuance, right, and so much individuality, that and that's where the topic of today comes in of of diagnostics, bloodwork, how to look at all these different lab tests, and kind of form a puzzle picture that you can see for the individual. But before we get into that, how long have you been doing this and how did you get into this work?

Shawn Bean  03:53
I've been doing this for approximately 15 years. One of the reasons I got into this was my own like many others out there and my own health journey. I was a national level bodybuilder, and I pushed my body to the limit and I started having circadian imbalances because I ran an article that you know, get up at three o'clock in the morning, you know, have your pre workout meal, go back to bed, get up at five o'clock and train. Well Being young and dumb, I didn't understand circadian pattern back then. So what that was doing was that was setting my immune system for malfunction that went on for a while and I noticed that I started to have GI tracts for the last competition and everything was on par, it was as soon as I got done the competition, my immune system was so compromised that out of celebration, bodybuilders go to sushi bars. And we were there for well over six and a half hours. I probably gained 22 pounds of water fluid. We actually had to take one of the people to the ER room, because he gained like 30 pounds he had to get least six done because of they were so depleted. But what I learned there was is when you go get sushi, don't ever go to the all you can eat sushi places, because the handling of them, it may not be as par, they don't go to the market at the right time, you have the leftovers and hope they don't have contaminations. And within 48 hours, I just wasn't feeling well. So I started to get bloating and constipation. I felt my system slow down, I got you know, all the symptoms of what I now know is dysbiosis. And also the amount of sushi I had, practitioners that I might have had a Mercury overload from it, because I had close to 125 pieces on top of Hibachi bar. But I didn't have no alcohol and I did take my ginger, I did take my ginger capsules during that time. The other thing that led up to this was, I started to go on this salad kick. And one of my meals would have been, when I look back, the amount of oxidants I was taking in was astronomical, I was probably pushing anywhere between 1.5 grams to two grams of oxalates a day for a prolonged period of time, about eight weeks, because I would go through two bags of spinach, because I thought spinach was good for it, you know, and I'd make a spinach salad. You know, this huge spinach salad with nuts and berries like everybody talks about, and I'd have cottage - I have a little bit of cottage cheese because I found that lactose intolerance didn't go well. So you know, we were doing yams, we were probably doing, you know, 12 ounce yams. So when you figure that out, you know, bag of spinach, you know, I was I literally was going through 10 to 15 bags of spinach a week. Okay. And that's where I kind of started putting the pieces together just probably in the past. I'm like, wow, I just created Oxalic disaster. Okay. And then enter my contest, I started to feel slowed down, I started to have no GI related problems. And normally you gain weight coming back off of contest, because you eat four, you know, three - 4000 calories a day. But my weight wasn't coming back. I normally gained between 15 - 20 pounds after contest. It wasn't coming back, like was, so right then told me that I probably had a parasite or had something going on gi related. You know, I went to the doctor, like listen, man, I'm 200 - 215 pounds, I normally go to 235. Okay, and something's off. So they took some blood work and the first thing I noticed was the alkaline phosphatase was low. It was in the low 40s. That was 15 years ago, I picked up on that. So after I got that done they ran my testosterone level came back 35 Okay, now do I admit, being a bodybuilder I used, you know, we have to compete. We used anabolic steroids. But the thing was, is I stopped them way before, you know, coming into contest because I like to go in, you know, dry, so to speak, and the dosages I was doing was a drop in the bucket, compared to what other guys were doing. You know, a lot of guys go, "Dude your'e natural." Okay. Because I relied on training, I relied on, I have great genetics. And I could pretty much know my body. My old training partner was Dr. John Berardi from precision nutrition. We used to travel three hours, two or three times a week to go train, we did for a year and I learned a lot from him with his massive eating program that we were doing way back in the early 90s, you know, early 1990s. But things just weren't right like testosterone, oh, you're just a little bit low on testosterone. So the guy wanted to get me like 2.5 milligrams androgenic, which is a total joke. But things progressed. And I started to have neurological conditions, which were more of a schizophrenic, where I started hearing voices. That was probably the neurological excitation coming up from the glutamines and low GABA and I was also doing glutamine at the time. So it's trying to push that up even more. Once you understand the metabolic pathways, you can go back look, you go back and look to see where he screwed up, you know, and actually reconstructed from a reverse engineer standpoint, that's the way I approach stuff is reverse engineering. You can give me the test, I can reverse engineer to give you the gene expression to give you the symptoms, and you know, or go symptoms, give you the test results without even seeing the test results. So by reverse engineering that I'm like, wow, this is, you know, gut. And then I moved into a house that had black mold -- on top of this, so I was helping out a friend who was paraplegic, who was actually, he had cerebral palsy. So probably just within past three years my mom was yeah, we're cleaning up black mold off the off the kitchen floor, okay, because he couldn't take care of himself. So here I was in this moldy area and next thing you know, within one month, I woke up total amnesia, stuttering with shakiness. I didn't know who I was where I was for over three hours. And that was when the neuro lot that was when my day changed. That's when the journey really begun. Okay. And the repair. So, I worked with a couple of functional medicine doctors, they're like, well, you're, you know, they put you on thyroid, your thyroid is low, thyroids low. The next thing you know, you push your adrenals down, so they didn't do adrenals. If I was going to kick myself, one of the tests I should have done and spent the money should have been in the adrenal profile that they had back then. If I would have done that, I would have known what was going on. I went to a naturopath, and he's like, Candida, like, okay, and your liver is congested. And everybody told me I had congestive liver, congestive liver, congested liver, but they couldn't break through. And when I did the stool sample test, nine months later, after losing 100 pounds of lean muscle tissue while eating 3000 - 4000 calories a day. It came out like nine different types of infections. So they put me on this protocol, I guess. And guess which one it was, Cipro. They put me on zip row, which later I found out that I was floxed. Because I guess was in 2011 they came up with a black warning blackbox warning. I just, and Genova just had their genetic profile done to tell you what drugs so here I am, I just did this $400 genetic test to tell me that I was, I shouldn't do fluoroquinolones. Okay. Now, what happened was is I had a stool sample testing done from the very well parasitologist in Arizona, and he picked up some parasites, and he said, Hey, you got to use Gentamicin for it. Okay. And I'm like, okay, so I went in, they didn't have Gentamicin. So they gave me (unintelligible) which was Cipro. And then the other one. I'm drawing a blank. It's another fluoric hormone outside of that they use for sinus infections. Just drawing blank right now. But they gave me that one as an alternative to Gentamicin. And within two days, I felt like my I was going to rip my shoulders. I was working out and I felt like it was going to rip right off the bone. Levaquin I think it was, they gave levaquin. And within like, a couple of days, and then I went to the gym and then when my friends was like, I haven't seen for a while I'm like, Oh, what happened? I tore my shoulder. I tore my Achilles, I tore this. I said, What did you do? He said, I went in, they gave him Cipro. So he actually was repairing all his muscle damage from all the stuff that you know, from Cipro then. And then a couple other bodybuilders I know have been damaged from it too. And I actually helped develop a lot of the floxie protocols they use today. The NAD therapy, that was my that was my research. The high vitamin C was also my contributions. And the amazing thing was is I found eight of the genetic genes associated with being a floxed, within 30 minutes, I did it - I did it on a podcast with Jesse Arime, Dr. Jess Armine. And if you were talking floxies, they were talking floxies these nights went in and did all the mitochondrial research. And a lot of those genes today are now found on a lot of the genetic testing with someof my contributions.

Matthew Blackburn  15:25
Well, Shawn, just to define, can you define being floxed? Because a lot of my listeners probably don't know what that means.

Shawn Bean  15:32
What floxed is, is when I look at history, I always want to look at what medications they've taken in the past. And if you had what's called fluoroquinolones, which is Avelox, Levaquin or Cipro, there is potential damage to ligaments. There's also literature anecdotally supporting that once you stop them, you still have mitochondrial damage that continues as a result. So and not everyone's going to respond to that. So I do know a lot of practitioners I work with that are in generalized medicine from talking to me, they, they use it as last resort, but a lot of ones will give it to you, if you know, UTI infection. Here's some Cipro. Okay. But remember, it also can be life saving because Ciprofloxacin is also one of the antibiotics that you're less likely to become resistant to. So it's - it's a clinical call on the practitioner but if you're coming in, if a female comes with UTI, you just don't give them Cipro as first line of defense, and a lot of practitioners do. So being floxed basically means taking this medication for whatever reason, and having a negative reaction to it that can affect your tendons and ligaments, specifically in your shoulders, your calves. And not realizing like, whoa, you know, that makes sense that it happened right around that time that I was treating gut infection that they gave me Cipro for or that they gave me Avelox for Levaquin for sinus infections, okay, 5 - 10 years ago. So, as a clinician, we have to look at that and clinical history as a potential. Because if people have not gotten it, people have not gotten better, you have to dig and dig. And one of the clinicians that I really enjoy is Dr. Peter Rouse. And one of the things he told me, he said, You keep asking yourself why, and you can't ask that you keep asking yourself, why you can't ask no longer. And that was probably the best piece of advice to me as a commission is keep digging, keep digging. And then it's like, when I was sick, I was on a forum and I actually, one of the testing results that I actually caught was low ceruloplasmin and low copper. And that was - that was in 2004. I caught on to that but nobody knew what it was. Nobody understood. Okay. And here's where my clinical experience comes into that. There are a lot of practitioners out there that have done incredible research into different areas but this is what I found to be true. When you correct the underlying cause, the ceruloplasmin and the copper levels will start to rise on their own. I have had multiple cases of mold. I had multiple cases of glutathione that was not properly being recycled. And you start to see them rise as a result. And as I mentioned before, the glutathione oxidized versus reduced ratio, I feel is the number one identifier of a person's resistance to disease. And as a clinician, you can get as a clinician, the clinician can order this test through HDI, which is a laboratory out of New Jersey and they can do an a la carte from the practitioner and it will probably be one of the best $140 that you can spend, because if you know that ratio, you know what's, what approach is to take and what not to take, you know, to give, you know, not to give the wrong glutathione or it's going down the wrong direction to where you think glutathione is good for us. And actually, it's making matters worse. But at least with this ratio, it will give you an indication of what pathways to work on. You know, your glutathione know your GSR, your GST's, your other pathways, your nerve 2 pathway because a lot of people that take glutathione don't respond well because their nerve 2 pathway's not working. Because nerve 2 pathway has been shown to increase glutathione synthesis, it increases the transfer asis, it also helps with the recycling tip. And one of the best things I found to utilize with that is actually the hydrogen water tablets. They have been a profound effect. And I like the idea of modulating nerve 2 versus trying to force it. Because your body turns on and off and the hydrogen water tablets taken appropriately will modify will modulate that. I'm always about modulation that in the body go in the direction supposed to and not try to force things when it's inappropriate. So getting back to your question, because I digressed a little bit

Matthew Blackburn  21:44
It was great!

Shawn Bean  21:46
So the copper ceruloplasmin were first things nobody knew what they were. And what that did was is that led me into my that cyclic pattern thinking like a dog chasing its tail and that's what a person on the forum who identified that, Shawn, you're autistic. I'm like, "What do you mean?" He goes, "You have classical signs of autism." And when I went back, I looked at when I was younger, I was, had all the classical science, I would flap my hands I would make gurgling sounds, but the weird thing was is I was antisocial but what weird thing was is I was an athlete, and that made the diagnosis, or that kind of question, whether I was autistic, but I went to child development because I had an extremely high IQ, but I was dyslexic. Okay, I had a speech impediment. I didn't speak until I was four years old. Okay, now I know that actually that came from a gene expression called GAMT. GAMT is a gene expression or pathway associated with creatine. That's why a lot of autistic kids I work with, I give them creatine, L-carnitine and what that does is it works on all those pathways to support the methylation and also to sport the mitochondria. And just by doing that, that's why a lot of autistic kids are hypertonic. They have hypotonia they lack creatine, soon as you give them creatine next, you know, they're building muscle, they're actually being able to swim. I've had cases where within five weeks, the guy comes back, he's like, Shawn, my son is now swinging on the jungle gym. What did you do? Okay, and sometimes it's just something simple. You know, give him epsom salt bath, get them talking, you know, work on sulfation pathway. And sulfation pathway is one of the factors that is necessary for copper dysregulation. Big time. And, you know-

Matthew Blackburn  24:04
I was gonna say, Shawn, you just brought up the, the GAMT gene and that's, that's one big reason why I wanted to have you on the show is, you know, I just interviewed the, the CEO of SelfDecode where he uses like, you know, AI algorithms and polygenic risk scoring. And I've been trying to learn how to read it. I mean, they make it stupid, simple with the health reports, but you can actually search individual genes, and then see, you know, what, you know, mutations you have. But my friend, Dr. Tyler Panzner that I had on the show just told me this morning, he's like, "Well, just because you have an alternative allele, it doesn't mean it's bad. It could be a benefit if you just see that it's mutated." I mean, I hope we get to a place where it'll be easy to read ourself but-

Shawn Bean  24:54
Number one thing is is I don't follow genes no more. The reason being is, If you know the gene expression, do you need to see them on paper? Like, for example, I have people that come to me, they're like, I'm, I'm calm, or here's how I learned about this. I wouldn't say the word killed, but could have. What happened was is I learned about gene expressions through two hippies. They were 70 years old, they were organic farmers. They were anti aging specialists. Okay. Perfect Health. They came to me because I was a genetic guy. Okay, so here's what happened. They came into me with the only triple homozygous CBS pathways that I've seen so far. Okay. So what did we do? We dropped sulfur and molybdenum, right? Well, guess what? You need sulfur to control what? Blood pressure and heart rate. Okay. So you drop the sulfur, add the molybdenum. What does that do? Wipe sulfur out of your body even faster. So, think about the gene expression. You're like, Oh, my God, homozygous, triple homozygous, never expressing. What did it result in? Two different types of blood - blood pressure medication, with a beta blocker for the heart. Because it shifted them so fast, because I dropped their sulfur and increased the molybdenum to 500 micrograms, which was a specific regiment back then, okay, to do. And that's when I learned that, like, when they were catastrophic, and they were in their 60s and 70s, driving, and they were basically bed bound. So I'm like, "Listen, stop." And they were able to get off the blood pressure medicine, regulate their system. And that is the lesson that I learned that just because you're read doesn't mean you give us specific supplements. Because if I didn't know what I was doing, then, they could have progressed and I just changed those little variables. Because when I make recommendations for variations on variables, it's methodically changed up every three four days, and is strategically placed upon the individualized biochemistry, the gene expression, and also taking consideration, look upstream, downstream, sidestream, because we have to be able to look not just ahead, you know, like, for example, if you have a person who's comped and they have MTHFR. And you give them five methyl folate. Well, guess what? That's going to push the gas pedal in the comp. You know, I had people contact me with MTHFR. Drive into the hospital when their heart attack and at 150 - 160 because the practitioner told them to take two or three milligrams of 5-methylfolate when their comp was express. That's why when I've revamped my approaches, methylation is down at the bottom. It's sulfation, glucuronidation are the top because everything trickles from there. Because what happens is, it's called the sulfation bucket. You have your phenols you have your histamines, you have sulfation and you have the glutathione. Okay, what happens is, is when your sulfation bucket gets overloaded, it's going to overflow it, your histamines are going to start to overflow, then your phenols are going to overflow. And then the phenols feed into the bucket, knocking down the sulfation pathway because of the fact a lot of the organisms inside your GI tract -- are phenyl producers. And what they're trying to do is, is they are trying to regulate the microbiome, to shift it, to an adaptogenic response against something. So when you see (unintelligible) when you see that what looks pathogenic. It is most likely an adaptive state. Because hydrogen sulfide is one of the mechanisms our body produces glutathione as stated in a study that I provided on my Facebook, it's one of the mechanisms. So what happens is, hydrogen sulfide rises up. Look at the hydrogen sulfide producing organisms. Okay you normally see on one stool sample test, okay, they're trying to help out because your body's not getting glutathione because the sulfation pathway is jammed. So once you un-jam that sulfide, you know, you may have to reduce phenols, you may have to reduce - may have to bring an epsom salt bath. Okay. I've given epsom salt bath to autistic children when I know that they had a phenol sulfotransferase issue. Okay, it gets jammed, 80 - 90% of them have. Doctors aren't looking at it. They looked at it long time ago, but they're not looking at now. Okay, so guess what, you remove the phenols, you give them a little bit of the no-phenol, and then you work on the pathway by giving them epsom salt. The epsom salt bypasses the digestive tract because the sulfur comes in, the hydrogen reducing bacteria, get a hold of it, produce hydrogen sulfide or hydrogen sulfate, you know, and then that feeds back into the sulfation pathway getting jammed up again. So you're getting - what I've done is, I've learned these negative feedback loops. When you look at the body from a biohack standpoint, you've got to pull yourself back and look at things on a three dimensional holographic view. Not one dimension, traditional medicine looks at one dimensional function medicine - functional medicine is a good starting, but their philosophies have to change. I don't follow a lot of functional medicine anymore. I don't like their philosophies. They're getting too much into marketing. Not all but some are getting in too much marketing and pushing supplements. And a lot of practitioners who were really good practitioners have gone off into the social media realm and are doing protocol based. And I have a lot of clients and even practitioners come back to me it's like, yeah, following your protocols almost killed one of my clients. Okay.

Matthew Blackburn  31:57
Yeah, like every, almost every protocol has that story. Right? It's fascinating. And you mentioned glutathione, a bunch, a lot of people listening to this are probably going to be like, "Well, what about my liposomal glutathione?" I remember going to the Bulletproof Conference, years ago, and they were handing that out like candy, a little syringe, you know, at the orange flavored, liposomal glutathione. Could that actually harm people? If what you're saying-

Shawn Bean  32:24
Remember, it's the type of glutathione. Okay, it's gotta be recycled. If they give you a reduced glutathione, there's a less likelihood that it's going to go to oxidize. Okay, but here's the thing too. When you're looking at a lab, you got to know is, is it the synthase, is it the recycling or is transport system? Okay. Like when your organic acid test, for example, this polyglutamic acid, okay. First of all, a lot of practitioners don't know how to interpret that test. Okay. Here's the reason why. And I have had - I've watched people when I - when people send me their labs, you can see when their well is draining, and goes bone dry. Okay? Because what happens is, is your body, your polyglutamic acid rises first. Okay, that means that you're just draining - that you got well, and you're draining it. Okay. It's as fast as it's coming in, it's going out. Over time, what happens is that well starts to go dry. And what happens is, is you'll see the flip, you'll see the polyglutamic acid go to the lower end. But because it's at the lower end, it's identified as non clinical. Which is not true. Because I've seen mine, okay, you could see where my mold exposure happened. You could see how my, you know, phase, you can see how my phase one, phase two liver shifted to more hippuric, okay, because the sulfation pathway was - the sulfation and (unintelligble) pathway, and it really depends on the type of mold that you have which pathway gets handled. Okay. So, with that being said, I know people are doing glutathione for mold when maybe the mold that you have is more glucuronidation pathway. Maybe you need more calcium glucarate. I just worked with a very prestigious practitioner who was very, very sick, and she was not responding to glutathione and we knew she had a phenol problem. Okay. And once we took care of that phenol problem, added the epsom salts, added the glucuronidation with the calcium glucarate, she was able to tolerate glutathione Okay, she had vitiligo, vitiligo is from a glutathione deficiency. It's from mold exposure, which she had, okay. We reverse that and what happens is when you look in clinical studies, fetal toxicity is one of the major causes of vitiligo because it's a toxicity in the body. There was a study produced out of University of Massachusetts that confirm that. So when you have a phenol overload, what you're doing is you're overloading your sulfation pathway. When you overload your sulfation pathway, you're draining - you're draining the swamp with glutathione. And also glucuronidation pathway, because that's the backup system. Glucuronidation is the backup system when everything else goes down. So when you're talking about Dave Asprey using calcium glucarate, he was smart about that, because the calcium glucarate actually was able to take some weight off -- of the other pathways to the catch up.

Matthew Blackburn  35:45
Interesting. Wow, have you used ozone therapy, Shawn, my, my friend, Charles Barber got me into it, like insufflation and the ear insulflations, rectal insulfations, and I've seen studies that that increases glutathione synthesis. Also ascorbate and, you know, obviously, kills pathogens and has a lot of benefits. Just wondering if you've ever experimented with it or use it with-

Shawn Bean  36:09
I have experimented with it but clients have - they use a lot for blood ozone, they do a lot with ozone for blood in regards to -- in regards to pathogens, specifically. Sometimes ozone feel good, but because they might have a superoxide dismutase blockage or that pathway is not working because superoxide is the backup system for glutathione. And then a lot of times you see uric acid levels go high. When uric acid levels go high, uric acid levels going high when there's no presence of doubt, that's like an antioxidant. That's basically when your other systems are down. Okay, because a lot of times uric acid goes up in (unintelligible) If you have a ketogenic diet and you're more prone to gout, a ketogenic diet, when you do - when you're prone to gout can cripple you. It put one of my colleagues into a situation to where his uric, you know, you're trying to lose weight, he was doing a keto diet. And next thing you know, his gout - he ended up in the hospital. He had to, you know, learn to all walk again, because it was really, really bad, you know, so, that's why specific diets may not work for everybody. And a lot of people on the Bulletproof Diet I've seen a lot of people the Bulletproof Diet with their CAC's going up into the several hundreds, even to 1000s. Because they're doing this saturated fat and they're APOE44 which they need to be, you know, APO34 and APO44 gotta be careful with saturated fats. Because APO44 what happens is, I found out that number one, your demand for K2 goes way up. Okay, and what K2 does is K2 works off a principle called PXR and when you look at and study for PXR, what it does is just insane. It actually is one of the major mechanisms for liver regeneration. It works on the phase 2 pathway and helps all the major antioxidants in your system, that nobody's looking at. It helps to make sure calcium goes in the right spots. It's - K2 is actually anti estrogenic itself. So K2 has been highly overlooked in its potential. K2 is also one of the most powerful ways to detoxify xenoestrogens itself. So you know, that's why when it comes to K2, I normally have people you know 200 micrograms, 300 micrograms, or if they want to do the Japanese food, they could do that if they wanted to.

Matthew Blackburn  39:00
Do you think, Shawn, that's why people don't respond well to - like I sell vitamin E and I promote Rosita cod liver oil and sometimes people will say it gave me this crazy rash, this crazy reaction and the substance was toxic. And you know you're promoting something as toxic and I was like well maybe you were depleting you know like the old Weston A. Price thing was take the cod liver oil with the butter oil to get the K2. Out of nowhere the vitamin E was coming in that group but I think there's a balance of those four right A, T, E and K and-

Shawn Bean  39:33
Yeah, cuz um, I think one of my colleagues Michael McAvoy, he was looking into vitamin E and we found that was wheat germ oil was like one of the highest sources that you can actually apply topically to get vitamin E because vitamin E is one of the - vitamin E can actually go inside and get into the bloodstream from topical application. A lot of times glutathione, I may have applied topically to the like if somebody has Hashimoto's, I might take Quicksilver or, you know, different forms of glutathione and have applied directly to the thyroid. And next thing you know, you see the antibodies come down. Because you're getting directly at the autoimmunity within the thyroid itself. You can also add flaxseed oil rubbed on to the thyroid, I've lowered antibodies that way. So there's a lot of things that you can do. And the thing with cod liver oil, you have to watch out for, is when you look at the red blood cell -- fatty acid profiles, you see high levels of DHA to lower levels of EPA. And what's happening is is that is actually an indication that the body is going more to a mitochondrial dysfunction. That is also causing what's called DAMPs and PAMPs to activate, which is not good because that causes mitochondrial dysfunction, that cause oxidative stress. And that usually means the body's in the potential cell danger response -- as a result. So again, the analysis of - the analysis of lab work by using (unintelligible) has been paramount, and knowing when to supplement and when not to supplement cod liver oil, because I had all - I have several autistic kids that were on cod liver oil. And once I pulled them off cod liver oil, and worked on regulating their arachidonic acid by manipulation of leukotrienes and the phenols - because what happens is the phenols from the phenol sulfur, transfer his pathway actually stimulate the leukotrienes. Then the leukotrienes go and stimulate histamine responses in the mast cell. So if you shut it down from the source, that's how fish oils work. Fish oils is shut down the leukotrienes. But there's another way you can do it. Okay, leukotrienes go through what's called a five locks pathway. Okay, five locks pathway is one of the major sources. That's why that one singular works so well. It's a locks - five locks inhibitor and if you look at the studies, as I dug into it further, what he found is is - I shared that study with a clinic that's a hyperbaric down in Florida, they were blown away by how Singulair may be able to be used to control leukotrienes and to reduce neurological inflammation, in a lot of cases because the literature is out there. Another way to lower leukotrienes can be fish oils. Okay. But with fish oils, you have to be extremely careful, because the source, and also a lot of fish oils are just not EPA.

Matthew Blackburn  43:04
Have you seen the PRM. So that goes pro resolving mediators,

Shawn Bean  43:08
Pro resolving mediators are very interesting, I need to do a little more research on them, because I noticed that a lot of companies are adding them in. Very reputable companies are starting to add them in, they may be able to modulate all those things, but through the work of Michael McAvoy, who's bringing back (unintelligible) he's getting deeper into how to use different lipids to get the same results and knowing when to utilize some, which is amazing because he's - he, from the results that he told me. He's like Shawn, he's like I had this person, you know, had this incredible, you know, inflammation and it was gone within 15 minutes. So, such a great person to have on.

Matthew Blackburn  44:00
That's awesome. Yeah, I love to. So I have a question for you, Shawn, if my genetic report says, "Likely higher levels of arachidonic acid" based on, you know, FADS1 and 2, what would I do for that? If I've -

Shawn Bean  44:20
Number one is a lot of the times in red blood cell you'll see, you'll always see a inverse relationship with Omega6 and Omega3's. What that basically means is, is the correct - you always want to have the parental high and come down. But what we're seeing in the red blood cell we're seeing just absent. We're seeing the ALA on the lower side, despite, you know, taking in walnuts and things like that, and that's a metabolic shift. Okay. I see a lot of people with low ALA. And I always refer to it as cellular incest because the parents give birth to the kids not the other way around, you know, doesn't go one way but if you look at the omega6's, you can see how it starts high and comes down low to DGLA to GLA interact (unintelligible). Okay? In your situation, this is what I would do. Okay, from what information that I have, there's two different options number one, take your urinary pH. If your urinary pH is acid, then therefore your body probably needs a little more sulfur or you have problems with sulfation. Okay, if you are more alkaline than most likely you're probably higher the alkalinity is more likely gut infection. A lot of people that have UTIs usually have high alkalinity, people with severe dysbiosis will have alkalinity of 8.5. And also when you're looking at alkalinity, Dr. Sircus, this information is awesome. And using bicarbs is a huge factor because bicarb deficiency has a huge input because I don't get too much into that, you know that alkalinity and diet for cancer and stuff like that. I just had a case that they went to a clinic, they put her on high alkaline diet, it accelerated the tumors. Because what happened was is her body was so alkaline her body started produced acids against it, counteract it. And once we shifted her back from plant based diet, more to a higher protein, moderate diet, lower, you know, foods, she was probably also at the time I didn't think about it oxalates too. She'd probably get oxalate overload, which was probably adding inflammation and her body because of her microbiome couldn't address it. You know, theoretically I think she had low Bifidobacterium, theoretically, I think she had you know those organisms because Bifidobacterium helps the good to great oxalates itself. And you know, if you're running FUT2, combine with FADS, combined with PMT combined with you know, APOE and you have mold, you're definitely in danger zone, okay? Because number one not producing (unintelligible) to help get it out. Number two, the APOE44, you know, that stores it so you have harder time getting rid of it. Okay, then you got the heavy metals on top of that, and then you got the FADS1 and FADS2, you know, you're gonna pee mast cell activation, like crazy. Okay, so getting back to your question, Using your (unintelligible) approach, they have what's called a bound sulfur. And the bound sulfur is utilized when the - this is Michael's work, when the acid base balance is below 6.2. When you're more alkaline, you would use a different formula. The other thing that I would use is number one, boswellia - frankincense, those are the two most powerful, that's how they work. They actually are 5 locks inhibitors. When I looked into the research, they're all 5 locks inhibitors. And they also work on the COX that works with the COX2 pathway as well. So you're getting you know, that's why when you give an autistic kid frankincense and put them in epsom salt bath, they they get dramatic results because you're shutting down the major inflammatory pool, you know, you're shutting down the inflammatory cytokines, okay? You're also shutting down the leukotrienes because they're in the epsom salt bath because you're shutting down the phenols, you shut down, you shut down leukotrienes it's the phenols that signal the leukotrienes to leukotrienes that signal mast cell, so that's why when you look at some of the research in regards to stabilizing phenols they use high dose fish oils because what they're doing is they're using officials as a modulation for guess what? The leukotrienes.

Matthew Blackburn  49:07
Interesting. Shawn, so like when you start working with a client, do you - do you have tests that you tell everyone to get first because I have not had much blood work done you know my first I sent you some of it, maybe we'll have time to get into it a little bit but my first test was in 2016 - 17. And now I'm in a place where I'm excited to do you know the ion panel and already have that siting here. I have a GI stool map downstairs. I just started doing the OmegaQuant tests I plan to do there - there was the Omega3 where they look at 24 fatty acids not just the DHA and EPA.

Shawn Bean  49:53
That's the one that I utilize that's mainstream practice and you can pull mold out of there you can pull (unintelligible). You can pull hypothyroidism, cellular hypothyroidism, you can pull, you know, the leukotrienes, you can see the you know when to use, you know when to use in your primrose oil, when to use GLA based upon you know, yeah your GLA is low, but if they're running estrogen dominance, you don't want to use even primrose oil, because it's estrogenic. So therefore you may want to use GLA barrage oil or (unintelligible) oil so that that $99 test will tell you more information, when it's properly interpreted. I mean it cross reference, it gives me an indication that there's cell danger response, then it tells me if there's mold or lyme on the radar, it tells me if there's a pathogen above, it tells me is your thyroid working. Tell - you know, tells me nutritional deficiencies, because once you understand the pathways, we're just reverse engineering, you know, and all these people that are zinc deficient, they're GLA deficient, is what it is. GLA when you look in clinical research, it actually inserts itself into the zinc keyhole to activate it. So if you're coming down with zinc deficiency, your GLA is going to be low but if you try zinc and zinc and zinc and zinc, more zinc you get it's not going nowhere well guess what? You need GLA it activated. And that's all in clinical documentation.

Matthew Blackburn  51:28
Do you think the zinc sulfate test is accurate like the taste test where you swish it for 10 seconds in your mouth? A teaspoon, if it tastes like water, you're deficient?

Shawn Bean  51:39
It's questionable. Same with the alkaline phosphatase. The Alkaline phosphatase is supposed to be a zinc driven enzyme, but actually - it's actually when you look at it, from a clinical standpoint, it's copper dysregulation but it all goes back to glutathione, (unintelligible) choline, it goes back to B12, indirectly and taurine. I just found an article that I think I posted up about how taurine increases alkaline phosphatase. And then you wonder why your B12. deficient? Well when you're B12 deficient, you piss out taurine like crazy. And that may be one of the reasons why the gastrointestinal tract is the mucosal barrier. Because when you look at the - when you look at taurine, what it does is it starts a whole cascade of the enzymatic reactions in your digestive tract, hydrochloric acid, pancreatic enzyme released bile flow. Studies have shown in cystic fibrosis that were resistant against pancreatic enzymes, they give them 1000 milligrams or so of taurine per meal and guess what happened, their stool sample test, their steatocrit literally dropped in half. You know, and when you look at the GI MAPs test, I mean, my cutoff is like eight, when it gets above eight on the Steatocrit, that usually tells me it's clinical, and then usually alerts me that, hey, there's a SIBO going on. There's other you know, bile issues going on. But a lot of times mold and SIBO and they all goes back to your bile flow. And then it goes back to your thyroid too. You know -

Matthew Blackburn  53:11
So when you say your B12 deficient do you mean in the cell not in the bloodstream because my - as maybe you saw in my lab work, my B12 was really high but my transport was really low. The binding capacity transcobalamin and -

Shawn Bean  53:27
What I found - what I found about the transforming pathway, or the whole transcobalamin, I mean, when you when I looked at your lab test, you have to transcobalamin, but it's also called holotranscobalamin. Okay. That's usually it's, you know, there's TCM1, TCM2, TCM3, I think it's the TCM2 pathway. And what happens from that situation usually tells me again, you're getting that competition for the hydrogen sulfide, that carbon monoxide, that nitric oxide, maybe you have - maybe having more of an iNOS versus eNOS pathway going on. Maybe you have an infection going on, that just has not been caught. Okay, so as it was mentioned in earlier talk, the carbon, the carbon 1 metabolism is kind of like looking at the - kind of like the revenge of the nerds. It's kind of like the bullies versus the nerds. I explain to my clients about this. And also two, it's like, you're trying to get 100 people onto a school bus. It's just not going to get there. Okay, because the transport system. So what you have to do is you have to overload the transport system. Okay. And I found clinical studies showing pharmacological standpoint, that people and actually we are way behind in this in regards to research, the British are way ahead of us. Okay, UK has this under control. Okay. And what you're looking at your cases, you're looking at a potential sub clinical case of Pernicious anemia. Okay, And what you would want to do is is orally, my, my - I was down at 373, okay? And normally you'll see low alkaline phosphatase, which is probably somewhere under 80. Okay? Or you might see methylmalonic acid on your urine high as a subclinical result, okay? So in that standpoint, you have to treat it like Pernicious anemia, okay? But you have to make sure that the hydroxy you give, you know, to hit pharm a lot, for it to hit pharmacological standpoint, you're probably looking at somewhere between five to you know, your serum levels shouldn't be up around the five to 10,000 mark, to override that mechanism. Okay. That's why a lot of the practitioners, old school, they'll give you 5000 milligrams, or 10 grams when I was under a specific practitioner, where I made the biggest gains was I was using IV PC with glutathione, because I had mold. I mean, I turned around the fastest within six weeks, I had my gut healed, I put, you know, I went from benching to 225 to 315, back to 315 for sticks. And my weight started coming back on, that was because I was using (unintelligible) choline and doing glutathione, IVs. And I was doing and I was on a regiment for the methylation, because what they were trying to do was is - she was trying to backdoor it. Okay, she loaded you up on a lot of riboflavin and we did not have molybdenum, we did not use molybdenum at all. Because what happens is we - I use uric acid as an indication of molybdenum. Okay, if your uric acid levels are low, then you're probably a little deficient. Okay. If your uric acid levels have high, then you know super high, then you want to think about, hey, you might have some copper dysregulation going on. Because uric acid and copper are highly interlinked. Okay, and when you look into clinical research about alkaline phosphatase, guess what? Guess what comes up, Wilson's disease. Okay, Copper toxicity as a potential mechanism.

Matthew Blackburn  57:17
Wow. So Shawn, when you say when you said serum levels B12, 5,000 to 10,000 to override the mechanism, I've been reading a bunch of studies the last few weeks on this and, you know, normal serum B12, or high serum B12, but low transcobalamin and how do you treat it. And I found three or four or five studies that said you have to do weekly -- was it, intramuscular injections of B12. Some studies say that's the only way you know, dissolving lozenges don't work. Liposomal doesn't work, capsules don't work, what are your thoughts and all that?

Shawn Bean  57:58
As I started to dig further, I found that glutathione may be one of the - glutathione, or glutathione recycling may be part of the equation. There was a study that I posted up about super, super, you know how you'd have super filled physiological amounts, but you need glutathione to activate. And glutathione is necessary to activate and -

Matthew Blackburn  58:28
To activate B12?

Shawn Bean  58:29
To activate B12. So your level - people want to look at minerals and stuff, you have to look at the activation of the cofactors. If you - reverse engineer the cofactors and know the metabolic pathways and cofactors work on, then it leads you to the situation. So like with you, I would probably see somewhat of a disturbance in the polyglutamic acid pathway, I would probably see that probably your glutaric was gonna be high because of your probably peeing out B2 potentially. Okay, and 90% of people that do the organic acid test, guess what? Their glutaric is always high. Okay? And then you'll normally see like, maybe you're pantothenic acid in high excretion, too.

Matthew Blackburn  59:12
So high glutaric acid means probably B2 deficiency?

Shawn Bean  59:16
Absolutely.

Matthew Blackburn  59:17
Okay.

Shawn Bean  59:19
That's the, you know, and that's your recycler. That's your sulfation pathway because when you have high glutaric you're not recycling - you're not recycling glutathione. So in those situations, if you give glutathione it might backfire. So when I look at the organic and when I look at diagnostic testing, I take the whole clinical picture in the board, what I do is, I said, "Oh by the way, have you done glutathione IVs you probably felt really, really bad on them." "Oh my god. Yeah. How do you know" I said, "You're not recycling." Okay. And what that does is by using the methylation panel from HDI or getting you know, those tests done, it just validates it.

Matthew Blackburn  59:57
It sounds like you use the OATs test or Vanic acids test quite a bit right for the pyroglutamic acid and the glutaric because it will show those two and more, right?

Shawn Bean  1:00:06
It will - that test does, that test for me, does over four to $5,000 worth of lab work. Number two, it also shows me about 14 to 15 different gene expressions. And what I did was is I crossed you know, I can actually get a Dutch test, reverse engineer it and tell what's going to come back on the organic acid test. I've done that before. I've been on the phone, talk to a person yeah they have and I had my organic tests sit in front of me, I said, "Yeah, number 53 is going to be on the high side, number 10 is going to be to the 10 is going to be to the right side." They're like, "How did you know?" I'm like "After you do 1000, several 1000s of these, just listen to the person's symptoms will tell you where the markers are gonna be, you know -"

Matthew Blackburn  1:00:51
Is the ION test because I have that I'm just waiting to make the time to do at the ION panel is that similar to the organic acids or?

Shawn Bean  1:01:00
It's similar, it's similar. But what I do is is I've learned to utilize other tools that people have it great, okay. But you can still pull majority of the data from the organic acid test, generalized blood work, and the OmegaQuant. You know, because they'll make quant and the information that they provide on there is not accurate. In regards to they have the arachidonic acid set one, you know, and I cross referenced it, you know, you're in the range, you know, being at like 45. Okay, when you look at clinical data, you know, in my clinical experience with arachidonic acid EPA ratio between four to seven, and I have people that are actually clinical at 10. So the diagnostics from what these interpretations are, could be slightly skewed, in my opinion. Plus, with the organic acid test, I know how to skew the results, to get to show me the clinical picture. Because what happens is I have clients come in to me and all their mold markers are dead smack in the middle. And I'm like, listen, after you take the creatine level and move it to the when you drop the creatine level down to 40, 45, 50, you're going to have a lateral shift so much to the right. And when I do that, that just totally changed the clinical picture. So if they're sitting on the yellow, that just moved them outside -- outside the range, and we're smack in the middle and it goes down low enough to 25 or 30, then you're way outside of range. So if you're sitting on the outside of the range, and you were, you know, and your clinicians like, "There's nothing wrong with you, but you're totally symptomatic" you know, and because they don't look into the nuances into the different, you know, like, wow, you have a person whose pyrimidine pathways are not working right, which are folate. And then they're just a little bit on the inside of a little outside the range, but not coming up. And you have a mother who's having miscarriages and you look and you're like, what type of - I'm taking folic acid. But okay, you're having miscarriages? Well, they said, a practitioner said my folic was fine. Now, okay. Number one is this is indication, this is not metal. Okay, this is folinic acid. Okay, so what happens? You have a mother who's had miscarriages, and just from that simple, organic acid test you can say, by the way, some unknown person who's 45 years old. Have you had miscarriages in the past? There like yeah. And it was, you know, and I do it off the cuff. And like, "How do you know" I said, "Well, you're MTHFR is expressing your folic acid pathways are down. And all they had to do was give you probably folinic acid, and a little bit of five methyl and you would have been fine as a result" because in our twins, I was monitoring my blood work of my wife and her MCV started at the low at 90 and we're on a fifth and we're on like 1500 milligrams of combination of folinic acid and five methyl. Okay, we saw MCV starting to creep up -- because of the twins, so what we did was is they went from 90 all the way up to like 96 or 97, it went up dramatically. Okay, so that told me the methylation was fine. So we actually added more folinic acid to compensate for it. Okay? Because it was, it wasn't a high risk, but I just wanted to take precautions. And when I work with my clients that are pre, you know, preconceptual counseling, we do the organic acid test. And when I take clients through, what happens is nine out of 10 people, I'm like, listen, based upon your genetics, based upon the data, based upon the clinical presentation, you need to wait six more months. Got to clean out, okay? Because when they conceive, that's, you can't detox. You can, but it's very difficult. So, if you get them six months to nine months ahead of time, you know, I'm saying create super babies, but that's what I have done. Most of the babies that I work with the parents come back, you know, Shawn, I can't thank you enough. I can't believe that I was going, I was spending $25,000 on fertility drugs, when nobody looked to find out that there was a toxic mold in our house. Okay. Or the fact is, is Wow, because I had cellular hypothyroidism even though my T, you know, my TSH was normal, everything was fine, because of other factors going on at the cellular level that you found glyphosates okay. You found glyphosate guess what that causes cellular thyroid dysfunction, and when your thyroids off or iodine deficiency, I even have multiple cases that were I gave them PQQ. And guess what? Boom, because you need mitochondrial function for the conception, and also the developments. Okay, so a lot of children being born mitochondrial dysfunction because of toxicity.

Matthew Blackburn  1:07:26
Yeah, and deficiencies. My girlfriend and I have been diving really deep into the work of Robert Krypton, some people call him the dean of iron biology on planet Earth and kind of butcher his work completely. So we've been posting quotes verbatim from him. And a lot of women go into pregnancy, completely iron deficient, and not even anemic nor normal hemoglobin, but iron deficient, ferritin below 30. And I just posted something yesterday on lysine in relationship to iron and hair loss. But I guess that amino acid L-lysine helps with iron and zinc uptake and like that alone has increased, increased ferritin, for some people.

Shawn Bean  1:08:08
No, what happens from that the pathway that works on is lysine increases docking P5P. Without lysine, you don't dock P5P when you don't dock P5P you don't have activated 6. And when you don't have activated B6, you're gonna have form of iron anemia. That's you know, you need B6 activated form of B6 to activate the iron to do its job. One of the workarounds that I do for that is this. Use lactoferrin. Lctoferrin will increase your ferritin levels but you have to use the right one. There's APO, and then there's the other one, you want to be careful because the APO actually can lower the like ones from like life extension. We use them in iron toxicity a lot because it manages that. Okay. But there are clinical studies out there and a lot of people I've worked with that when I use lactoferrin somewhere between three to 600 milligrams, they start to see the ferritin start to rise. Okay, especially in pregnant women-

Matthew Blackburn  1:09:17
So what's the form for deficiency if apo's for overload Do you remember? Was that holo? I'm losing track of all the different words for all the-

Shawn Bean  1:09:30
There's you just don't there's only like a few forms of apo E I believe yarrow, I believe yarrow has one and then I know like (unintelligible) has one.

Matthew Blackburn  1:09:42
Oh here Yeah, I just searched there three different forms of lactoferrin, apo, like you said iron free, which it may be why it has that affect, and then monoferric has one ferric iron, holo lactoferrin, I was close, has 2 iron ions. So either one of those maybe.

Shawn Bean  1:09:57
Either one of those maybe or, you know, you can also use colostrum. Colostrum has a little bit of lactoferrin I believe it's 50 milligrams per serving. But, you know, the other thing you can do too is is I believe you can use taurine to raise it up indirectly. Okay? Because taurine is a amino acid that is a big workhorse, it's overstated. We give our children 500 I know it sounds crazy, but since we've been given our children 500 milligrams of taurine, you know, 250 to 500 milligrams, taurine a day, they sleep better, their vocabulary has exploded. You know, we, they just one of them just turned 2 and to do the alphabet all the way up from up to ABCDEFG.

Matthew Blackburn  1:10:53
Wow. So what do you say to people, Shawn, that like are the food only people because I get a lot of those like, supplements are a scam that's all marketing every you know excetera, just get it from food, just eat red meat, go carnivore or whatever for your, your iron your amino acids. Do you think often food is not enough to correct imbalances?

Shawn Bean  1:11:15
Foods, foods is not enough because due to our world, we live in our metabolic demands, our gene expressions. I mean, 20, you know, 20 years ago when we had real food, okay, I'd say yeah. Okay. But now, I mean, look, glycine going to - you know, glyphosate is going to - glycine and molybdenum out of your system. Okay, flat out. So that's why you see a lot of people with liver dysfunction, because the glycine and then you know, the glyphosate inserts itself into the, you know, mimics glycine, okay, through the work of Dr. Stephanie Smith. Okay. But, you know, I'm more - the prime example about that when you have a person that you do a workup on, and then you can calibrate, I calibrate people's individual IVs based upon that, and you just see the amazing change, okay? Because the United States is like the United States of inflammation. That's why they call it -- we're inflamed. Okay, our guts are in a wreck. Now, we're eating all kinds of crap food, and it's just not bad, but it's like, walk outside of your condo, you're gonna get smacked with glyphosates. Okay, you live in a condo, you're gonna get electromagnetic, you're gonna be fried by electromagnetic fields. Okay. Yeah.

Matthew Blackburn  1:12:46
I've been loving Doris Loh's work on EMFs and melatonin but but ascorbic acid blew my mind, it blew my paradigm wide open of Whole Foods see being safer, even though it contains the ascorbic acid, even though it increases iron absorption, Whole Foods C is not better than ascorbic acid, I would say ascorbic acid is better to get into the high doses of raising ascorbate.

Shawn Bean  1:13:12
The thing about raising ascorbate is is number one, look how many years that the rodent Institute has been doing vitamin C IVs. Okay. And reducing cancer. Okay, that alone should tell you enough. Okay. I mean, yes, you got to be careful what kind of, you know, IVs you do, because you don't want corn or anything like that, you know, you gotta get stuff from, you know, corn free and GMO free and stuff like that. But the thing is, is, you know, there's a lot of approaches I question that I think they do have merit, but I think people get so locked into it. It becomes almost like a cult following and I don't follow, I look at the trends. You know? Trends, it was, you know, hypothyroidism and then it went to adrenals and then it went to methylation and even before that, it was no cures or curezone.com. Okay, back in the day, you had the one person you know, the PD, you know, the psyllium and sillimanite bentonite clay, okay. I forget her name, but she was always promoted.

Matthew Blackburn  1:14:38
I remember Cure zone and that was back in the day.

Shawn Bean  1:14:41
They were ahead of their time. Okay, they were doing they were on the phone. Okay. Then you got you know, yet Cure zone. You had Candida. You know you had the Candida rush and you had the liver rush and you had the, you know, the hypothyroidism then you had the hypo adrenal, then you had methylation. I mean, you just see these current trends in medicine, that, you know, we become rats scurrying. You know, trying to find the next magical potion or pill.

Matthew Blackburn  1:15:13
And I think it can be fun for curious people like us. I mean, I like trying a bunch of stuff. But for people that are just trying to get well and balanced, it can become frustrating, right?

Shawn Bean  1:15:24
Very frustrating, because I mean, you go on a Facebook hook, you go into hypothyroid, Facebook, which I've seen many, many clients from, they come to me, and it's like, "I have hypothyroidism." And they dig and you look at the, you know, the dynamic relationship, they're in with her husband or boss, you know, and they're sitting there, eating mickey D's now out of depression. And I'm like, listen, "I understand what you're trying to do but I think you need a marriage counselor instead." Okay, so as a clinician, you can't have that one rice bowl. Okay. And I think that's what we're starting to see is, as one of my friends said, "Everybody's got to protect the rice bowl." And that's what makes what I do very unique is, is I take the wonderful work of all those practitioners, okay. And what I do is, is I look at the pros and the cons, then I dig deeper into, you know, Okay, this looks good, but is it clinically relative? What kind of data to support? You know? And that way, how can it be used applically, you know, how it can be used clinically, to get a better outcome? So my philosophies and approaches are a conglomeration of hundreds of practitioners over the years. And what I've learned to do was is I've learned to find out what works, what doesn't work, why it doesn't work. And that way, I can relate it back to the peoplesaying, "I want on this protocol." I'm like, "Okay, this works well, for you, because of your gene expression and these pathways being blocked. You should have done these three steps first, before moving on to this one." Okay. As you said, it doesn't just become a puzzle and the number one factor that I find in clinical outcomes is the order. And everybody asked me, Shawn, what is your protocol for mode? What is your protocol for lyme? What is your protocol for this? I said, "they are - they do not exist." Okay? Because protocol for me is a four letter word. It's the best way I can explain it to people. And when people come in, you know who they've been to. Because you look at the sheet and like, "Oh, you went to this doctor, this doctor", "How did you know?" I said, "When you see multiple times, you know where they're coming from." Okay.

Matthew Blackburn  1:18:00
You answered a few of the Q&A questions, because we had a bunch of people asking about protocol for lyme protocol for Candida all these things.

Shawn Bean  1:18:09
Well, here's, let me let me explain in a nutshell, basically, what happens. Number one, what you need to do is is need to find out, why can't the body adapt to its current environments. What factors are preventing that, then you have to go in and look at what the factors are, then the pathways that are being altered. Okay, I'll give you an example. I worked for lyme, I shifted the whole lyme, train of thought. My, one of the doctors was severely pissed, because I actually found the connection between manganese, manganese and lyme. Because I was on a doctor, I was actually personally invited by one of the top lyme doctors to go into a research forum. I put in my information and guess what happened in 2010, I was talking about manganese, and I posted about my findings, what happened 2014 They found out and they posted a study about it. So - which is fine.

Matthew Blackburn  1:19:15
Lyme feeds on manganese you're saying, right?

Shawn Bean  1:19:17
No, actually, manganese is deficient because of the oxidative stress caused by the lyme.

Matthew Blackburn  1:19:24
Oh, wow. Because you always hear a pathogen eats a metal right, like pathogens feed on iron or pathogens feed on-

Shawn Bean  1:19:30
I had a client that was seeing a prestigious lyme doctor, and they read that and they pulled all their magnesium. Next thing they know. I told them and called them and said this is not appropriate and they weren't too happy about that. But guess what? Their client almost ended up committing suicide because when they dropped this magnesium down, they went to into a suicidal mode.

Matthew Blackburn  1:20:02
Wow.

Shawn Bean  1:20:03
Because they pulled all the magnesium feeds lyme, don't do it. I had her on (unintelligible) had her stabilized, everything, she was doing great. Nope. Doctor pulled it and I got this call, frantic email, I'm like get back on your magnesium.

Matthew Blackburn  1:20:17
Wow, it's scary how these nutrient deficiencies really affect someone's behavior and emotions. Like the B12 documentary I was watching last night some woman that just had a baby, had - was having thoughts of killing her newborn baby. And she was diagnosed with severe B12 deficiency, they treated it she stopped having those thoughts. You know, and same with suicidal thoughts or, you know, it's I think a lot of this emotional instability comes back to nutrient deficiencies. Right? Imbalances.

Shawn Bean  1:20:53
Yeah, I would have to agree 100% about that. And, you know, those are the types of cases that you look, if you have suicidal thoughts. You know, when you have the MTHFR, I discovered by looking at the multiple, you know, when I get a report that has multiple MTHFRs, the first thing I'll ask is like, is there history? Has anybody in your family immediate family, committed suicide or tried to commit suicide? Okay, and then I'll have people will go back - then you start asking around, like, they'll come back to me, Shawn, I don't know, how you know this, but I had an uncle who committed suicide. So by looking at that, you're able to tell and potentially predict. And again, it's, I'm just sharing my clinical experiences with them saying, you may want to go back and research this a little more, see if you find anything. And it was not a second, or third uncle. It was a first uncle. That was a distant uncle, that not too many people had contact with. So it was in the family history and she had no idea. You know, so that's why when I've actually been on calls to where people were, you know, told me that, Shawn, I can't thank you enough. Because I told him is, as I said, based upon your genetic predisposition, you may feel like, if you go down that dark road, that, unfortunately, you're going to be more likely to go on autopilot. And I told people to when you get to a certain level, before you get to the autopilot, let people know, I had several women providing the information was during genetics. I had several calls, thanking me for saving their lives, because it was a prediction on because once you go down that dark road, sometimes there's just no turning back. But have you kept yourself, before you start to go there saying, oh, Shawn, Shawn told me about this. You know, he alerted me to that -- from the consult, and it saved a few people's lives.

Matthew Blackburn  1:23:14
That's incredible. That's awesome. I have a question for you, Sean. Like, electrolyte imbalance. This is something that I've been thinking about lately. I just got like Carolyn Dean's, you know, Pico potassium I've been taking that tastes horrible, but I shoot it. You know, the RDA for potassium is 4700 milligrams, which for me seems hard to get. I don't know. I know it's in meat. I know it's in potatoes. Fruit. I have none up here until I grow it myself. That's good. But what are your thoughts? Since you've been talking about magnesium of like, do you think a lot of people that have health issues, they don't have that foundation down of getting enough salt getting enough potassium.

Shawn Bean  1:24:02
It really depends on a lot of different things. Number one supplements like I have a lot of people come in to me that are taking licorice root, and have you just - so you'll often see that they'll be dumping potassium as a result. Because licorice root, potassium, okay, you can go high, you can go hypocalcemic on them. Okay? So you have to be very, very cautious about that. Number two, you've got to look at what condition are you treating? Okay, first of all, man, water balance is controlled by the adrenal glands. water balance is controlled by the hypothalamus in regards to the antidiuretic hormone, it's caused, you know, kidneys, aldosterone, renin. So when people start dealing with these conditions, you really have to dig deep into, you know, the endocrine system controls a lot of water and electrolytes and stuff. So oftentimes, when you have like antidiuretic hormone, you're going to need more sodium, and potassium, if you're going to have pots, you might need the balanced out with more potassium, but no more potassium and sodium, or maybe vice versa. So, when it comes, you know, even with B12, if you take too much B12, there's a potential that you can lower your potassium levels from it. Okay, but your potassium levels are controlled by the adrenal glands. So if you're buying - and insulin too. So if you're hyperinsulinemic, you're going to have lower potassium levels. Okay,

Matthew Blackburn  1:25:55
Do you think it's relatively safe for most people to do the shotgun and take, you know, there's like these electrolyte powders, you know, Costco has now and you know, everyone, you can buy them everywhere. But those little, you know, electrolyte powders and stuff, or potassium chloride or whatever, like, do you think it's because they can't cause harm to most people - to take them, or?

Shawn Bean  1:26:15
I like to take a moderation approach. I like to save somewhere between one to two grams - supplement it. The one that I found, I liked the best is optimal electrolyte. And what I'll do is is I'll take optimal electrolyte and add a half teaspoon of sea salt to it and do that two times a day. And when it comes to electrolytes, you don't want to shotgun them. Okay? Would you walk into a IV place and ask them to do a sodium chloride push, no. Okay. They have to be trickled through. Okay. So I usually tell people to get good clean water, and add them in your water and sip them throughout the daytime. That's why you need two servings of them. Okay. And this way, by using a liter of water or whatever, you measure the amount of liquid you're taking in, too. And people don't know how much water they're not drinking. Okay, as a result, because, you know, I had one person that I said, try to get a liter, and she drank like one cup of tea a day, then then she wondered why she was having, you know, confusion, and disorientation and tried to blame it on lyme and mold. I said, "You're dehydrated." The other thing is, is when your arachidonic acid to EPA ratio is off, you are pushing cellular inflammation. So therefore, the water is not going to enter into the cell as it should. And we do know that lithium and taurine are crucial for allowing electrolytes inside and outside the cell to control osmolarity. That's why I like the optimal electrolyte from seeking healthbecause it's got the taurine in it already. It's got the creatine in it, it's got the sodium in it, I just - because I have people with low adrenals, they need a higher sodium to potassium ratio, because they tend to not hold on to sodium. And then if you have a mold person, sometimes we need to do the same thing because when the antidiuretic hormone levels are low, you're not getting sodium inside the cell. So you're gonna or you're putting, you're kicking out more than you're putting in.

Matthew Blackburn  1:28:47
I liked that - I liked that approach, because individualized because a lot of people, practitioners will say the ratio is this in the body of sodium and potassium for every single person. And that's not the case, right?

Shawn Bean  1:28:59
No, because if you have other things going on that will affect electrolyte balances. You know, that's why I focus heavily on endocrine system. The endocrine system is one of the major switches for turning everything around. When people come to me, a lot of the time it's I follow a system that it called BEG, Biliary Endocrine-System Gut, okay. That is where the magic happens, on top of foundational work, okay, because if you're riding adrenal insufficiency, and you're doing more potassium than sodium, you're making your condition worse. Okay? And sometimes you may have to do more potassium, you know, in certain situations and lower sodium in others. So, just because person comes in with adrenal insufficiency, I might have them do a 2:1 ratio of sodium potassium in the morning, but - and they're doing licorice root or anything like that, I may have a bump it up to potassium and more than 1:1 on, you know, when they start their licorice root. So it's always constantly shifting and changing based upon numerous parameters and factors. And that's why you always have to look ahead in these cases because otherwise, you're potentially, you know, doing unintentional harm.

Matthew Blackburn  1:30:30
And sauna use too, right? Like I have an outdoor barrel sauna, and sweating. You lose - I was actually reading - my girlfriend found the study, you lose more copper than iron, in a sauna, it's a significant amount of copper, it was one to two milligrams or something like that.

Shawn Bean  1:30:48
Yeah and the thing about sauna is, is it's going to stimulate your lymphatic system, your lymphatic system is going to stimulate your bile, so you'll actually be increasing your liver capacity, you know, and then you get glutathione before going in, you even enhance them more. That's why when I have people that have mold toxicity and electrolyte imbalances due to adrenals or you know, estrogen, testosterone or what other - you know, kidney issues, you may, you know, want them to, you know, instead of guzzle, sometimes you may want to have do it before. Sometimes you may want to do sip on it during. So, you know, it really depends upon the person on how you approach. It's just not going in, you know, and sip on, you know, electrolytes, maybe you need beforehand. Okay, maybe you need them because of some - a unique scenario in your biochemistry that, you know, that just like working out, maybe you need a pre workout drink, rather than having that branched chain amino acids during your workout. Okay. So it's really, like you said, individualized, because you just can't shotgun things. And that's -

Matthew Blackburn  1:32:19
Sorry. Go ahead.

Shawn Bean  1:32:21
That's the major issue that I see in cases.

Matthew Blackburn  1:32:26
Right on. Yeah, I'm trying not to interrupt you but I have so many questions we'll have to do another round. But have you seen clients use cold thermogenesis because I went heavy into that for a while. And I thought I felt a benefit, definitely a brain buzz that lasted all day. Well, now that I live in a cold climate with the lake considering doing plunges, not soaks. I'm curious, your thoughts on it.

Shawn Bean  1:32:53
Because, you know, I have - because of mold toxicity and how it affects the stratum of the brain that causes dopamine balances. And what happened was, is I always felt better during the wintertime when I went out with no, you know, went out with barely any, you know, certain, you know, no coat stuff, I felt better. What happens is, is you're getting a dopamine rush, okay. And too much dopamine can be problematic depending upon your gene expression. But if you are DRD2 gene expression, to where you have a dopamine deficiency, because of the work from Dr. Blum, it's a Reward Deficiency Syndrome, then you're going to respond to the dopaminergic type of reactions, okay. So again, it's like you go to cold thermogenesis, that usually tells me that maybe your dopamine level might be a little bit on the lower side, okay. And that you need that boost, okay, it does boost your metabolism for sure. Okay. Either, you know, it's very similar to the chemistry of hyperthermic, versus otherwise it stimulates your metabolism, okay. It's a great way to increase autophagy.

Matthew Blackburn  1:34:16
Interesting, yeah. Yeah, I wonder with all the social media use. I feel like our dopamine is constantly under attack no matter what, even for guys not watching pornography, which is an issue with dopamine, right? But just being on the internet, I feel like it's a constant dopamine rush, right?

Shawn Bean  1:34:35
Yeah, it really is because what it does is it creates artificial adrenaline -- with blue lights added to the mix. And, you know, with lack of natural light, you create a huge circadian imbalance.

Matthew Blackburn  1:34:57
Absolutely, yeah. I want to ask you about this, Shawn, I recently had four cavities filled. That was my first dental work since having teeth pulled and I measured my highly sensitive C reactive protein back in 2016 and it was 10. I measured it again a month and a half ago, it was 10. And then I got the dental work done, I got a deep cleaning, they gave me the nitrous, they knocked me out. They - my gums were super, super sensitive because I was kind of anti dentist. There's that kind of trend right now in the health community where you don't need toothpaste or toothbrush or mouthwash. And you know, there's kind of that messaging going on. You don't need to see the dentist if you're on XYZ protocol or diet. And I kind of fell into that was like yeah, I could just do all my dental stuff at home. Oil pull, tongue scrape, I got this, went in - low and behold four cavities, and I was keeping them at bay. They weren't root canals, like most people have. It wasn't near the nerve, so obviously my K2 dosing was working, what I was doing was working, cod liver oil. I'm sure that helped. But I'm just curious if you've heard of that before, because people were saying, Oh, that's amazing that your gum inflammation brought your - solving your gum inflammation brought your CRP from 10 to, what is it, .5. But I'm wondering if the cavities were involved as well, or both because the dentist's was like, "Yeah, you had receding bone and gum, both." And this is you know, I drink coffee, but I swish with water after, I drink orange juice or whatever, I drink with - I swish with water. So very cognizant, but since then, I got an electric toothbrush, my brother inspired me, Sonicare I do the Waterpik and stuff. But I think that's kind of an overlooked cause of inflammation, right, like dental issues and being anti dentist.

Shawn Bean  1:36:58
You bring up a very good point, because when you look in clinical studies, periodontal disease is one of the major increases of C reactive protein. And periodontal disease is linked into cardiovascular disease. And one of the reasons being is if there's an infection because of the location, it's directly into the bloodstream. You also have oral microbiome present. So when you have an infection, and people may not know, they turn - tend to be more mouth breathers than nose breathers, you're affecting the oral intolerance, and the microbiome. So you can do oral - you can do all your oil pulling. But the oral intolerance and the gut microbiome are bi-directional. So you mentioned that you're doing a GI MAPs test. So it'd be interesting to see if your prevotella is going to be high. And the prevotella is usually indication that there's some type of dental issue going on. Because oftentimes, when prevotella is high, that usually indicates the next question I ask, "Have you had root canals, or had cavities that were filled that may have been affected?" And usually, it's a high probability that they have in the past. So it'd be interesting to see how your, your microbiome reflects that.

Matthew Blackburn  1:38:50
Are spore based organisms, probiotic therapy helpful for the prevotella - overgrowth or?

Shawn Bean  1:39:00
Spore based probiotics hit a wide range of organisms. I'm more of a prebiotic guy and post biotic guy. I like specific fibers. I like specific short chain fatty acids that are end products. When I look at the microbiome, I'm looking at what's deficient, why is deficient and the end products of what they create.

Matthew Blackburn  1:39:37
Have you used Floraphage? You ever use those Floraphages? That's a prebiotic.

Shawn Bean  1:39:42
I have not used Floraphage but I'm very familiar with Bosch approach to how they go in and they you know, they kill off the bacteria and then the dead bodies become food for the bacteria. One thing that I really stay fast on, I don't believe in doing a lot of killing. I've seen too many traumatic experiences for that, when it was not necessary. So I tend to shift the microbiome to create the optimal terrain. And as I mentioned before, sometimes the pathogens may look pathogenic, but they may be shifting as an adaptive state to try to help us out when specific pathways are not working right. So, a person sees H. Pylori, well H. Pylori is a hydrogen sulfide producing bacteria. And most people with H. Pylori, if you look on their organic acid test, you're gonna see the sulfation pathway jammed. So, what happens is, the H. Pylori is potentially pushing hydrogen sulfide to get to the end game, which is glutathione. But unfortunately, because of environmental toxins and nutritional deficiencies, we get stuck. And we produce more hydrogen sulfide than actually hydrogen than actually sulfate.

Matthew Blackburn  1:39:42
That's interesting, wow.

Shawn Bean  1:40:18
So, sometimes in that situation, that's where the work of Dr. Greg Nigh, (unintelligible), questions that the microbiome is trying to help us out. And a lot of the organisms that I started to look into are phenol producing, and phenol producing bacteria are actually very protective in helping out with mycotoxins. So, again, we have to question, is that clostridium rising up? Because it produces the toxic phenol as a defense mechanism. Or is our microbiome trying to shift it to try to get to a specific pathway, that we're not providing substrate for? And that's where using the epsom salt baths, that's where potentially using glutathione as I believe I provided documentation, how glutathione was actually used to eradicate H. Pylori, and the Mucosa. Well, my question there is, was it eradicating it, or did the body see it as negative feedback loop? Saying, listen, I got glutathione coming in, I got sulfur coming in. Guess what guys? You don't need me no longer. So we need to look at the microbiome in a - with a different set of lenses. And-

Matthew Blackburn  1:43:13
Oh, sorry, go ahead.

Shawn Bean  1:43:15
Change the functional medicine philosophy of kill, kill, kill kill. When you're potentially doing more damage to the microbiome, especially with people that have - I have people that have been on protocols for 6 to 12 weeks of using heavy antimicrobials and it actually, it may took care of SIBO. But in the interim, it caused other problems because they were on it too long, or they were on the wrong probiotic or prebiotic as a result, so.

Matthew Blackburn  1:43:58
Do you think the, that yeast therapy - was that beneficial yeast that people supplement that to - for H. Pylori? I'm blanking on the name. Oh Saccharomyces boulardii.

Shawn Bean  1:44:11
Saccharomyces boulardii, has been a godsend, because saccharomyces what it does is it increases the secretory IgA. When you increase secretory IgA, what that does is that's kind of like the patrol guard. And I, when your secretory IgA is down, it's kind of like having a traffic, having a crossing guard, who's drunk. And you've got Canadians coming across and Americans coming across the same border. And he decides on which one goes through and who doesn't without looking at passports. And that kind of what's happened to secretory IgA is, it's a tagging system. It tags what's good and what's bad. What to let through what not to, what to react to what not to react. So when your secretory IgA is down, your immune response, not just in your microbiome but all your mucosa, your nasal, your mouth, your lungs, vaginal areas in females are also susceptible to those immunological challenges, and it's just not organism, it's also environmental toxins like mycotoxins, mycotoxins will lower your Secretory IgA. And what saccharomyces does is saccharomyces actually has been shown to increase secretory IgA and also increase alkaline phosphatase. So, when you increase alkaline phosphatase, you're actually increasing the mucosa response. And also alkaline phosphatase is necessary for releasing specific enzymes to help us break down different foods on the mucosal wall. So, there's a lot of practitioners out there that are hesitant about giving, saccharomyces, I tend, if a person is immunological and challenged, I may go easy with it. Otherwise, you know, you can use it pretty strongly. And it's really, what it does is it helps to create the scaffolding for the beneficial bacteria to take hold. And it crowds out the pathogenic bacteria itself. So it does help with not just H. Pylori, but it creates a scaffolding for the other beneficial bacteria to take hold, especially people with FUT2 usually have low alkaline phosphatase. Because the mucosal barrier is more inflamed because of the FUT2. Because you're you're going to have a high potential of having low bifidobacterium and you have FUT2, you're gonna be more susceptible to dysbiosis. And then, when you work in genes, everything works in a synergistic standpoint. So if you're FUT2, you have PEMT, you have SHMT, guess what, you're going to be more prone to go leaky gut as result, and just not from bacteria but also, you're going to open up the door to mycotoxins a lot of people that have gut dysbiosis, have problems with mycotoxins because that helps to set up the - when mycotoxin setup shop, what they do is is they, you know, they help degrade glutathione which helps to replace the mucosal barrier, okay, you need glutathione to seal it. You need your vitamin E to seal it, so if your glutathione deficient, you're gonna be vitamin C deficient, you're gonna be vitamin E deficient, you're gonna be Coenzyme Q10 deficient, because glutathione helps those nutrients work more effectively.

Matthew Blackburn  1:48:21
And they mess with the NRF2 pathway, right?

Shawn Bean  1:48:24
They do mess with the NRF2 pathway and when you mess with the NRF2 pathway, glutathione, nitric oxide, and superoxide all get dysregulated as a result, you know.

Matthew Blackburn  1:48:40
Wow, with all this talk about the benefits of sulfur and we talked about taurine. It's interesting, you know, being in the supplement world because that's the fascination of mine, to study them - you know, I've heard and I've said this before, magnesium chloride baths are better, quote unquote, than magnesium sulfate. But now I'm thinking, what if someone's sulfur deficient? What if that sulfur with the magnesium in that float tank, or whatever, is actually more beneficial because they need sulfur more than chloride? Or, you know, I've also heard the argument that you're taking magnesium for magnesium, why would you take it, you know, magnesium, taurine or magnesium glycinate. But we need taurine and we need glycinate, right? Or glycine for glyphosate, so there are benefits to taking these bound forms, right? Of you know, sulfur, taurine or glycine to magnesium. The magnesium might be a small part of it, you know, out of two grams maybe you're only getting a couple 100 milligrams of magnesium but so what, amino acids are super powerful, right? For so many things.

Shawn Bean  1:49:51
Here's what I found about the chelates, I've been taking magnesium glycinate 600 milligrams before going to bed for years and the pathway that's associated with the uric acid on the organic acid test, which is the glycine pathway -- is still high. So I question whether those glycine molecules are actually getting utilized by the body and they're just a transport system. Second one was is I had a client, female, who had sulfotransferase issue going on, which I caught on her DUTCH test because her DHEA total was high and her DHAS was low. And four weeks she came back to me, I said, "How you doing?" She goes, "Sean I lost weight." I said, "You did?" she goes yeah, she goes, It didn't stop - she goes, "I was using magnesium chloride. And then as soon as I switched over to the sulfate, that's when I noticed that my inflammation start to go down."

Matthew Blackburn  1:51:00
Wow. Shawn, I'm so sorry, there's a freight truck on my camera. I was not expecting a delivery today. Can we just do like a 5 or 10 minute bathroom break? Is that cool? I don't know-

Shawn Bean  1:51:12
Yeah, I kind of got to get going because of-

Matthew Blackburn  1:51:17
Are we around two hours? Oh, that's right. Yeah. Okay, maybe we'll just we'll wrap it up and we'll have to do a round two, because I'm fascinated with your info. I lost track of time, I'm enjoying talking with you so much. But I get random, freight stuff and it's like, I don't even remember what this - yeah, he's looking for me. But, yeah, we'll definitely do a round 2 soon if you're up for it and, and dive deeper. I mean, I'll save these questions that people sent in. But yeah, this was this was amazing. Your website, I think I have it up here.

Shawn Bean  1:51:56
The best way they contact me - the best way to contact me because I'm revamping the website is my email address at matrixhealthwell@gmail.com.

Matthew Blackburn  1:52:06
Awesome. And you're taking one on one consultations, right?

Shawn Bean  1:52:09
I'm taking one on one consultations, I also am in process of, I do one on one with peer to peer. I'm working on - you know, I also do mentoring with clinicians to have them work one on one or do groups. Contact me, you don't have to be medical doctor or if you are, that's great. But I work with practitioners, like people who just want to get deeper, biohackers and want to get a deeper understanding.

Matthew Blackburn  1:52:38
I'll definitely be working with you, I'm sure. This was definitely a crash course. I mean, this is probably the most dense show I've done out of the almost 200. So I took a lot of notes, hopefully people did. I mean, so many rabbit holes that you talked about, I definitely want to go into more of those in our next, next show, and maybe have different focuses. But I think this could help a lot of people that have been looking for answers for many different problems. I really appreciate you taking the time, Shawn, and this was awesome and we definitely have to do it again.

Shawn Bean  1:53:14
Matt. It's a pleasure to be on the show and looking forward to our next show.

Matthew Blackburn  1:53:19
Right on. Thanks, Shawn. Stick around to close it out. That's a wrap for today's show. I love all the nuance that Shawn integrates into his practice because context is so important and I see that often missing in the natural health community, where it's everybody has iron overload and iron deficiency doesn't exist, or whatever extreme view that someone has. There's people with different genetics and different pathways that are more active than others. So I liked when Shawn shared his philosophy, that why can't the body adapt to the current environment? It's because you have to go in and find the pathways involved, and see which pathways are not functioning well, and then support those with individualized nutrition. And I think that approach is so valuable for people with chronic health conditions, because you can get to the root of why you feel how you feel. If you have fatigue, or memory problems or mood disturbances and imbalances, you can really go in and rebalance those areas of life just by having this individualized, nuanced approach. So that term being floxed is new to me. I have not heard of that, but apparently it's a big issue. And it's fascinating that Shawn pioneered the NAD therapy and high dose vitamin C as the remedy or even consistent vitamin C, with which is, what I do, I just take it consistently throughout the day, every hour if I feel like building up my body's ascorbate levels, and I definitely noticed an increased resistance to stress and just overall feeling better, getting my ascorbate levels higher. If you guys want to dive deeper into Shawn Bean's work, you can head over to matrixhealthwell.com. He provides consultations and I really think he offers such a great service with just such a balanced approach that can really help people to heal. If you want to check out my work, you can go to matt-blackburn.com. I have some blog posts there, recipes. If you click on shop, you can see all of my recommended products. And I just threw up the Ionic potassium up on the front page, on my website. Potassium is such a crucial mineral and if you're supplementing magnesium, it's a good idea to be on potassium because they work together so closely. And to retain magnesium you need potassium. And the RDA is 4700 milligrams, so that's quite a bit. And with this Ionic Pico Potassium, I just add it to a half 12 ounce mason jar full of water and down it. That makes me feel amazing actually feel it almost immediately. So huge fan of potassium supplementation. I've tried a lot of the different capsule, powdered forms and I feel the best so far on this Pico Potassium. If you want to check out my brand, you can go over to Mitolife.co. And a lot of really exciting things in the works. The Mito Life Drinking Water Filter will be released by the end of the year so that's very exciting. That's been a project two years in the making. I actually started my health journey with researching water quality. And I've spent several months to years exclusively on different types of water. And I really feel the best from this type of water that the Mito Life Filter makes. So that's it. I am headed off to get my first IV vitamin push. Going to see how I feel after that, really curious with all the buzz around it to just experience it for myself. Tune in every Friday for a new show and stay supercharged.